cancer-targeting compound 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13572	Cancer-Targeting Compound 1		Others
	Cancer-Targeting Compound 1 can be used in the study of hormone-related cancers, including the treatment or prevention of fibroids, uterine leiomyomas, polycystic ovarian syndrome, or hormone-dependent Cancer, among othe...		Others
T60155	PBRM1-BD2-IN-7		Epigenetic Reader Domain
	PBRM1-BD2-IN-7, a selective and cell-active inhibitor targeting the polybromo-1 (PBRM1) bromodomain, demonstrates inhibitory efficacy against PBRM1-BD2 with an IC50 value of 0.29 μM. This compound is utilized in cancer r...		Epigenetic Reader Domain
T60156	PBRM1-BD2-IN-2		Epigenetic Reader Domain
	PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 ...		Epigenetic Reader Domain
T62828	FRα-IN-1
	FRα-IN-1 (Compound 4) is a tumour targeting agent. FRα-IN-1 exhibits selective anti-cancer effects on FRα and FRβ expressing cells.
T74459	Y1R probe-1
	Compound 39, also known as Y1R probe-1, is a high-affinity fluorescent probe targeting the Neuropeptide Y Y1 Receptor, with potential applications in cancer research [1].
T63399	MTOR/HDAC-IN-1
	mTOR/HDAC-IN-1 (Compound 50) is a dual inhibitor targeting both mTOR and HDAC with respective IC50 values of 0.49 nM and 0.91 nM. It holds potential as an anti-cancer agent [1].
T40211	EIF4E-IN-1	eIF4E-IN-1
	eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1...
T61596	EGFR/HER2/DHFR-IN-1
	EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound specifically targeting MCF-7 breast cancer cells. It acts as a multi-inhibitor, targeting the EGFR/HER2 kinase and DHFR enzymes, with IC50 values o...
T61857	DNA-PK-IN-4
	DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly imp...
T61229	VEGFR-2/DHFR-IN-2
	VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 μM and 9.085 μM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, wi...
T75149	PROTAC BRD4 Degrader-19		PROTACs
	PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utility in cancer research [1].		PROTACs
T61315	HDAC6/HSP90-IN-2
	HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor targeting HDAC6 and Hsp90, exhibiting IC50 values of 105.7 nM and 61 nM, respectively. It is primarily utilized in cancer research [1].
T80921	Tubulin/JAK2-IN-1
	Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant antiproliferative effects against cancer cells [1].
T61498	Sulfisoxazole diethanolamine
	Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothel...
T79844	Anticancer agent 143		Phosphatase
	Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM. It is employed in cancer research [1].		Phosphatase
T74973	KRas G12R inhibitor 1
	KRas G12R Inhibitor 1 (compound 3) is a selective covalent inhibitor targeting the KRas G12R mutation, leveraging the high nucleophilicity of mutant cysteines to bind irreversibly within the K-Ras Switch II region. This ...
T79107	WRN inhibitor 1		DNA/RNA Synthesis
	WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain. This compound is potentially useful for cancer research [1].		DNA/RNA Synthesis
T74894	SIRT1/2/3-IN-1
	SIRT1/2/3-IN-1 (compound 10) is a potent, selective, and cell-permeable inhibitor targeting SIRT1, SIRT2, and SIRT3, demonstrating inhibitory concentrations (IC50s) of 0.54 μM, 0.253 μM, and 0.72 μM, respectively. It is ...
T79020	ALK2-IN-5
	ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].
T73923	Ep300/CREBBP-IN-4
	Ep300/CREBBP-IN-4 (Example 56), a highly effective inhibitor targeting both Ep300 and CREBBP, exhibits IC50 values of 0.024 μM and 0.064 μM, respectively. This compound is utilized in cancer research [1].